No, if three vectors do not lie in a plane, they cannot give zero resultant.

Explanation:

Let A, B and C be three vectors. If they give zero resultant, then

     A+B+C=0

or, A= -(B+C)

Hence, they will produce zero resultant, if A is equal to negative of vector (B+C). The vector (B+C) lies in the plane of B and C. Hence, A will be equal to negative of (B+C) if A, B and C all lie in a plane.

The two vectors (say A and B) of different magnitudes cannot be combined to give zero resultant since minimum value of combination is ІA-BІ which is not zero if AB.

The three vectors A, B and C of different magnitudes can be zero such that they form a closed triangle, then,

      A+B+C=0

or, C=-(A+B)

Hence, the sum of three vectors may be zero if vector sum of any two vectors is equal and opposite to the third vector.

Note: The vectors can give this result only if...