The two vectors (say A and B) of different magnitudes cannot be combined to give zero resultant since minimum value of combination is ІA-BІ which is not zero if AB.
The three vectors A, B and C of different magnitudes can be zero such that they form a closed triangle, then,
A+B+C=0
or, C=-(A+B)
Hence, the sum of three vectors may be zero if vector sum of any two vectors is equal and opposite to the third vector.
Note: The vectors can give this result only if...
A negative of a vector represents the direction opposite to the reference direction. It means that the magnitude of two vectors are same but they are opposite in direction.
For example, if A and B are two vectors that have equal magnitude but opposite in direction, then vector A is negative of vector B.
Any vector directed in two dimensions can be thought of as having two different components. The component of a single vector describes the influence of that vector in a given direction.

The Rh factor(the Rhesus factor or Rh antigen), is a protein that can be found on the surface of red blood cells. It is one of the most important blood group systems in human blood typing. The presence or absence of the Rh factor is denoted as either Rh-positive (+) or Rh-negative (-).
Fun fact: The Rh factor is named after the Rhesus monkey, in which the protein was first discovered.